UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS

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2025-07-06 14:20
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Conference: Bucharest University Faculty of Physics 2025 Meeting


Section: Polymer Physics


Title:
Preliminary Physico-Chemical and Biological Evaluation of Chromium-Doped Hydroxyapatite Embedded in a Poly(Vinyl Alcohol) Matrix and Enriched with Amoxicillin Coatings


Authors:
Liliana GHEGOIU (1,2), Daniela PREDOI (1), Carmen Steluta CIOBANU (1), Simona Liliana ICONARU (1), Teodora-France STEFANESCU (3), Mihai Valentin PREDOI (2)


Affiliation:
(1) National Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, 077125 Magurele, Romania;

(2) Department of Mechanics, University Politehnica of Bucharest, BN 002, 313 Splaiul Independentei, Sector 6, 060042 Bucharest, Romania;

(3) C.A. Rosetti Highschool, Giuseppe Garibaldi Street No. 11, 014192Bucharest, Romania


E-mail
dpredoi@gmail.com


Keywords:
chromium-doped hydroxyapatite, X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, metallographic microscopy, atomic force microscopy, Fourier-transform infrared spectroscopy


Abstract:
This study presents the development of a novel composite material consisting of chromium-doped hydroxyapatite embedded in a poly(vinyl alcohol) matrix (CrHAp-PVA) and enriched with amoxicillin (CrHAp-PVA-Ax) [1]. For the first time, ultrasound analysis was employed to evaluate the stability of the CrHAp-PVA and CrHAp-PVA-Ax samples [1]. Structural and surface properties were investigated using X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), metallographic microscopy (MM), and atomic force microscopy (AFM) techniques. XRD analysis showed that the addition of PVA and amoxicillin influenced the lattice parameters, unit cell volume, and crystallite size of the studied samples [1]. XPS confirmed the presence of chromium and identified chemical changes due to doping and antibiotic incorporation [1]. The results of the surface morphology analysis made by SEM, MM, and AFM revealed that CrHAp-PVA coatings exhibited a uniform and crack-free surface. The addition of amoxicillin resulted in a surface containing uniformly distributed agglomerates and increased surface roughness [1]. Preliminary information about the coating’s biocompatibility was assessed using MG63 cell line. The MTT assay showed that both types of coatings have a good cell viability, indicating their low cytotoxicity (after 24 h of incubation,). Microscopic observations confirmed that the cells adhered to and spread across the coating surfaces, suggesting effective early-stage interaction between the samples and MG63 cells [1]. The antibacterial activity of the coatings was evaluated against Pseudomonas aeruginosa ATCC 27853. Both samples demonstrated strong antibacterial properties, effectively inhibiting bacterial adhesion and proliferation [1]. Overall, our findings suggest that CrHAp-PVA based composites, particularly when enriched with amoxicillin, exhibit promising biocompatibility and antibacterial activity, making them suitable candidates as biomedical coatings for applications such as bone implants or antimicrobial surfaces.


References:

[1] Ciobanu, S.C.; Predoi, D.; Iconaru, S.L.; Rokosz, K.; Raaen, S.; Bleotu, C.; Predoi, M.V. Development of Chrome-Doped Hydroxyapatite in a PVA Matrix Enriched with Amoxicillin for Biomedical Applications. Antibiotics 2025, 14, 455. https://doi.org/10.3390/antibiotics14050455

Acknowledgement:
This work is funded by the Core Program of the National Institute of Materials Physics, granted by the Romanian Ministry of Research, Innovation and Digitalization through the Project PC1-PN23080101.