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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2025-07-06 15:47 |
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Conference: Bucharest University Faculty of Physics 2025 Meeting
Section: Biophysics; Medical Physics
Title:
The impact of stereotactic radiotherapy in the treatment of brain metastases
Authors:
Rareş Alexandru IONESCU STOIAN (1), Bogdan BIȚĂ (1, 2), Alexandru OPREA (3)
Affiliation:
1) Faculty of Physics, University of Bucharest,
2) Optospintronics Department, National Institute of Research and Development for Optoelectronics -INOE 2000, 409 Atomistilor, 077125, Magurele, Romania
3) Neolife Clinic, Brăila, Romania
E-mail
raresalexandru.ionescu@gmail.com
Keywords:
stereotaxy, metastasis, tumor, radiotherapy, treatment
Abstract:
Stereotactic radiotherapy (SRT) represents an advanced technique used in the treatment of brain metastases, allowing the administration of high doses of radiation to a small tumor volume with sub-millimeter precision. This method minimizes the exposure of healthy tissues compared to whole brain radiotherapy (WBRT), which involves the uniform administration of radiation over extensive areas, thereby increasing the risk of side effects. The evolution of modern techniques, such as IMRT, VMAT, and the use of linear accelerators (LINAC), has enabled the achievement of precise dose distribution, protecting critical organs and reducing treatment toxicity. IMRT uses complex algorithms to create precise three-dimensional dose distributions, dynamically adjusting the intensity of the radiation beam and thus ensuring a high dose conformity with the tumor contour, while simultaneously reducing the exposure of at-risk organs. Modern medical LINACs generate high-energy photon radiation (typically 6-15 MV), which effectively penetrate deep tissues and allow for highly precise treatment application due to integrated image-guided radiation therapy (IGRT) systems. These devices are equipped with multi-leaf collimators and advanced imaging systems, contributing to the further reduction of side effects and the enhancement of local disease control. The experimental part of the study included the creation and comparison of 10 WBRT treatment plans and 10 SRT treatment plans for the same 10 patients, selected based on criteria related to age, medical history, size, and number of metastases. In the experiment, differences in the doses received by the brain and critical organs, average survival duration, and observed side effects were analyzed. The results indicate that SRT offers significant advantages over WBRT by significantly reducing doses in healthy tissues, diminishing side effects, and potentially increasing the duration and quality of patients' lives. The high conformity and superior dosimetric precision of SRT have contributed to an enhanced treatment efficiency, supporting the use of this method in the modern management of brain metastases.
References:
Stoleru, L. (2014, 26 iun.). Radioterapia stereotactică, tratament oncologic modern. Viața Medicală. Disponibil la: https://www.viata-medicala.ro/*radioterapia-stereotactica-tratament-oncologic-modern-8730*
Bara, M. (n.d.). Totul despre radioterapia stereotaxică. Sanador. https://www.sanador.ro/radioterapia-stereotaxica-dr-bara
Institute for Quality and Efficiency in Health Care (IQWiG). (2022, 11 feb.). Stereotactic radiosurgery in brain metastases: advantages in comparison with whole brain radiation therapy
Zhang, S., Yan, D., Li, X., & Ding, X. (2021). Lung Stereotactic Body Radiotherapy (SBRT) Using Spot-Scanning Proton Arc (SPArc) Therapy: A Feasibility Study. Frontiers in Oncology, 11, 664455. https://doi.org/10.3389/fonc.2021.664455
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