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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2025-08-20 22:57 |
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Conference: Bucharest University Faculty of Physics 2025 Meeting
Section: Biophysics; Medical Physics
Title:
Radiobiology perspectives – past, present and future
Authors:
Mihaela DUMITRU (1), Mihai DUMITRACHE (2), Alina DUMITRACHE (2), Andreea UDREA (2), Claudia CHILOM (3)
Affiliation:
(1) Mihaela Dumitru _ “Sfantul Apostol Andrei” Emergency Clinical Hospital Galati, Romania
(2) Mihai Dumitrache _ ”Dr. Carol Davila” Emergency Central Military Hospital Bucharest, Romania
(2) Alina Dumitrache _ ”Dr. Carol Davila” Emergency Central Military Hospital Bucharest, Romania
(3) Claudia Chilom _ Faculty of Physics, Măgurele, University of Bucharest, Romania.
E-mail
1) mihaeladumitru11@yahoo.com
2) mihai149@yahoo.com
3) alinatanasemail@yahoo.com
4) claudia-gabriela.chilom@unibuc.ro
Keywords:
radiobiology, biological effects, molecular mechanism
Abstract:
Radiation therapy (RT) continues to be an important part of cancer management with approximately 50 % of cancer patients needing it at some point during the course of their diseases. Physics and biology are inextricably linked in daily practice of RT, and developments in both of them contribute to kill the tumors and to reduce the toxicity of normal tissues due to secondary irradiation. Radiobiology offers the knowledge on the biological effects of radiation and serves as a basis for radiotherapy and radiological protection. External radiotherapy (but not only) has provided most of the knowledge in radiobiology because it is the most used radiation therapy modality.
This presentation will provide the information regarding radiation chemistry, biochemistry, mutation and cancer induction, embryonic damage as well as the dependence of radiation response on radiation quality and temporal dose distribution. Also, will be discussed physicochemical events, cellular and tissue effects, and the molecular mechanisms involved in radiation response.
Radiobiology offers the conceptual basis for radiotherapy, identifying mechanisms and processes that underlie the response of tumors and normal tissues to irradiation and helps in development of specific new approaches in radiotherapy contributing to the choice of schedules for clinical radiotherapy.
References:
1. Basics of radiobiology. Jean-Pierre Pouget, Institut de Recherche en Cancérologie de Montpellier (IRCM), Inserm U1194, Université de Montpellier, Institut Régional du Cancer de Montpellier, Montpellier, France. https://www.researchgate.net/publication/358878550_Basics_of_radiobiology
2. Bentzen SM (2009) Dose–response relationships in radiotherapy. In: Basic Clinical Radiobiology, pp. 56–67. UK: Hodder Arnold.
3. https://cmcrcniaid.org/content/radiobiologylectures
4. https://www.thegreenjournal.com/action/showPdf?pii=S0167-8140%2824%2903406-6
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