Faculty of Physics - University of Bucharest

UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS

Guest
2024-11-22 1:40

HOME CONFERENCES SEARCH LOGIN NEW USER IMAGES

Conference: Bucharest University Faculty of Physics 2013 Meeting

Section: Optics, Spectroscopy, Plasma and Lasers

Title:

Matrix assisted pulsed laser evaporation of polycaprolactone-polyethylene glycol coatings for tissue engineering applications

Authors:

A. Visan(1), C. Nita(1,2), M. Miroiu(1), R. Cristescu1, G. Socol(1), N. Stefan(1), F.Sima(1), G. Dorcioman(1), N. Serban(1), M. Socol(3), L. Sima(4), C. R. Luculescu(1) , A. Stanculescu(3), I.N. Mihailescu(1)

Affiliation:

1. National Institute for Lasers, Plasma and Radiation Physics, Magurele, Ilfov, Romania

2. Faculty of Physics, University of Bucharest,Romania

3. National Institute of Materials Physics, Magurele, Ilfov, Romania

4. Institute of Biochemistry, Splaiul Independentei 296, Bucharest, Romania

E-mail

anita.visan@inflpr.ro

Keywords:

MAPLE, thin films, biomaterials

Abstract:

The recent studies have been focused on the development of biodegradable polymeric materials for biomedical applications. Degradable polymeric biomaterials are promising candidates for controlled release of drug delivery systems. Each of these applications requires polymeric materials with specific physical, chemical, biological, biomechanical and degradation properties to provide efficient therapy. In this study, we report polycaprolactone (PCL)-polyethylene glycol (PEG) deposition on 4CP titanium and double side polished silicon substrates via Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique. PCL is known for its excellent tensile properties, flexibility and biodegradability. Because of the high permeability to many drugs and non-toxicity, PCL was initially investigated as a long-term vaccine delivery system. PEG is recognized for its good biocompatibility and as a consequence of the fact that biocompatibility is growing up with the molecular weight of the polymer, we used two types of PEG, respectively, PEG10000 and PEG6000. It is noticed the general tendency of decreasing the solubility with molecular weight. MAPLE technique, considered the most convenient for the synthesis of novel organic delicate molecules thin films. MAPLE ensures good thickness control, patterning facility, and is appropriate for a wide range of materials to choose from. The technique is unique because it is able to combine these attributes into one processing tool able to deposit thin films and structures unachieved by other technologies. The aim was to obtain composite coatings with different biodegradation/ solubility’s kinetics with drug delivery applications. The composite coatings were characterized by Fourier Transform Infrared spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). Wettability tests put in evidence the hydrophilic character of the analyzed deposited thin films. We have concluded that the main functional groups of starting materials are present in the transferred film. All these results essentially signify that these biodegradable composite coatings are potential promising candidates for local protein delivery applications.