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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-21 20:41 |
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Conference: Bucharest University Faculty of Physics 2008 Meeting
Section: Optics, Spectroscopy, Plasma and Lasers
Title:
Increase of Cisplatin therapeutical index through optical irradiation: a case study of choroidal metastasis
Authors:
R. Fumarel 1, Gabriela Murgoi 1, P. Albert 1, Anca Hurduc 1,
M. L. Pascu 2
Affiliation:
1Institute of Oncology “Profesor Doctor Alexandru Trestioreanu”, Bucharest,
2National Institute for Laser, Plasma and Radiation Physics, Bucharest
E-mail
Keywords:
neoplastic tissue, optical irradiation, Cisplatin
Abstract:
The study has pursued the increase of the therapeutical index of Cisplatin by exposure of the neoplastic tissue to a beam emitted by a halogen lamp between 400-2000 nm. The Doppler ultrasonography has shown that, following exposure of the living tissue, the local microvascularization increases notably in a controlled and reversible way. Spectral absorption measurements have shown the lack of interaction of the Cisplatin molecules with the optical radiation. Therefore, the increase in the therapeutical index of this cytotoxic agent may take place by accelerating the intracellular hydrolyze processes ensuring the absorption of near infrared radiation (900-2000 nm) by the water molecules. The use of optical irradiation makes it possible to use Cisplatin doses 10 times lower than in the conventional chemotherapy. That, in turn, generates minimal secondary effects (kidney toxicity) while increasing the drug antineoplastic effect.
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