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Conference: Bucharest University Faculty of Physics 2012 Meeting

Section: Polymer Physics

Title:

Biocompatibility of Iron Oxide Nanoparticles Dextrin Thin Films Obtained by Spin Coating Deposition

Authors:

Simona Liliana ICONARU (1,2), Cristina Liana POPA (1,2)

Affiliation:

(1)National Institute of Materials Physics, 105 bis Atomistilor, P.O. Box MG 07, 077125, Bucharest-Magurele, Romania

(2)Faculty of Physics, University of Bucharest, 405 Atomistilor, CP MG - 1, 077125, Bucharest-Magurele, Romania

E-mail

simonaiconaru@gmail.com

Keywords:

iron oxide nanoparticles, thin films, dextrin, biocompatibility

Abstract:

Iron oxide nanoparticles (IONPs) doped dextrin thin films for biomedical applications were deposited onto a glass substrate by spin coating method. The particle concentration defined as the oxide/dextrin mass ratio, used was 1 and 5. IONPs-dextrin thin films deposited by spin coating were characterized using various techniques such as X-ray Photoelectron Spectroscopy (XPS), Scanning Electron Microscope (SEM) and Energy Dispersive X-ray Attachment (EDAX). These investigations revealed important structural information on polysaccharides thin films. The biological properties of the iron oxide-dextrin thin films were demonstrated using MTT assay test, with the aid of hFOB 1.19 osteoblats cells. In order to evaluate the cell proliferation rate of the hFOB 1.19 osteoblats cells on IONPs-dextrin thin films, the cells were incubated on the samples up to 4 days. Cellular morphology was investigated using FESEM to obtain qualitative information of osteoblast cells on IONPs-dextrin thin films. The data strongly suggest the potential use of iron oxide-dextrin thin films for biomedical applications. Note: Simona Liliana ICONARU was supported by the doctoral grant of the Ministry of Education, Research, Youth and Sport 2010.