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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-22 1:48 |
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Conference: Bucharest University Faculty of Physics 2013 Meeting
Section: Polymer Physics
Title:
Physico-chemical and antibacterial studies on silver doped nano-hydroxyapatite
Authors:
A. Costescu(1,2), C.S. Ciobanu(3), E. Andronescu(4,5), A.M. Prodan(4,6,7), L. Pall(4,8), P. Le Coustumer(2,9), F. Huneau(10), L. Marutescu(11), E.S. Barna(1), S.L. Iconaru(1,3)
Affiliation:
1 University of Bucharest, Faculty of Physics, 405 Atomistilor, CP MG – 1, 077125, Bucuresti-Magurele, Romania
2 Université Bordeaux 3, EA 4592 Géoressources & Environnement, EGID, 1 allée F. Daguin 18, 33607 Pessac Cedex France
3 National Institute of Materials Physics, 105 bis Atomistilor, P.O. Box MG 07, 077125, Bucuresti-Magurele, Romania, 1*simonaiconaru@gmail.com
4 University Politechnica of Bucharest, Faculty of Applied Chemistry and Materials Science,1-7 Polizu Street, P.O. Box 12-134, 011061 Bucharest, Romania
5 AOSR, Splaiul Independentei nr. 54, sector 5, 050094 Bucuresti, ROMANIA
6 Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari, sector 5,
Bucharest, Romania
7 Emergency Hospital Floreasca, 8 Calea Floresca, sector 1, Bucharest, Romania
8 ICMCB-CNRS, UPR9048, 87 Avenue du Docteur Schweitzer 33608, Pessac Cedex France
9 Université de Bordeaux, UFR Sciences de la Terre et de la Mer, B18,
avenue des Facultés, F-33405 Talence, France
10 Université Bordeaux 1, Avenue des Facultés, Bat 18, 33405 Talence Cedex France
11 Faculty of Biology, Microbiology Department, University of Bucharest, Ale. Portocalelor 1-3, 60101, Bucharest, Romania
E-mail
simonaiconaru@gmail.com
Keywords:
silver, hydroxyapatite, antibacterial activity
Abstract:
In this paper we report that preparation of Ag doped hydroxyapatite by an adapted co-precipitation method at 100°C has several advantages over other techniques. Specifically, it can generate highly crystalline nanopowder Ag:HAp which could be used for implantable medical devices. The XRD of HAp (xAg = 0) and Ag:HAp (xAg = 0.05, and xAg = 0.4) also demonstrates that powders obtained by co-precipitation at 1000C exhibit the apatite characteristics with good crystal structure and no new phase or impurity is found. The SEM results suggested that Ag+ doping had little influence on the morphology and dimension of the samples. It can be seen that all the samples consist of elipsoidal particles.The antibactericidal activity of Ag:HAp-NPs with xAg = 0, xAg = 0.05, and xAg = 0.4 on Bacilus and E.coli ESBL 1576 were presented. The Ag:HAp-NPs with xAg = 0.05, and xAg = 0.4 inhibited the biofilm development both by the gram-positive (Staphylococcus aureus 0364) and the gram-negative (Providencia stuartii 1116) strains.On the other hand, our studies have shownthat Ag:HAp with xAg = 0 had no antibacterial activity against gram-positive and gram-negative bacteria.
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