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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-22 2:05 |
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Conference: Bucharest University Faculty of Physics 2024 Meeting
Section: Solid State Physics and Materials Science
Title:
Advancements in Functionalized Magnetic Nanoparticles for Targeted Biomedical Applications
Authors:
CEZAR COMANESCU (1,2), GABRIEL SCHINTEIE(1), ANY SERGENTU(1), ANDREI KUNCSER(1), NICUSOR IACOB(1), VICTOR KUNCSER(1)
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Affiliation:
1) National Institute of Materials Physics, 405A Atomistilor street, 077125 Măgurele, Romania
2) Faculty of Physics, University of Bucharest, 405 Atomistilor street, 077125 Măgurele, Romania
2) Faculty of Physics, University of Bucharest, 405A Atomistilor street, 077125 Măgurele, Romania
E-mail
cezar.comanescu@infim.ro
Keywords:
magnetic nanoparticles, hyperthermia, morphology, XRD, cancer
Abstract:
surface functionalization of magnetic nanoparticles (MNPs) has revolutionized their utility in multimodal imaging, drug delivery, and catalysis [1,2]. A systematic study on the synthesis and characterization of magnetic nanoparticles (MNPs) has afforded by thermal decomposition of organometallic precursors hydrophobic and hydrophilic magnetite nanoparticles with average size in the range 10 – 50 nm. The shape of the resulting NPs was tuned with respect to size and shape, the synthesis being versatile enough to afford various morphologies from cubic, hexagonal, tetragonal to spherical. Notably, the MNPs exhibited narrow size distribution and high magnetizations approaching the theoretical value for magnetite. The influence of the synthesis conditions (concentration, type of iron precursor, molar ration, type of surfactant, temperature and time of thermal treatment) on the morphology, size and properties of the resulting MNPs were investigated by XRD, TEM, Mossbauer Spectroscopy and SQUID magnetometry. Using varying ratios of surfactants (oleic acid: oleyl amine), we established a clear correlation between MNP morphology and the nature of the surfactant system utilized. The synthesized MNPs were investigated regarding their cytotoxic effect by in vitro studies against cancer cells. In this respect, complementary hyperthermia studies were undertaken in order to establish the SAR value for as-synthesized magnetite NPs, the study being extended on the cancer cell culture for gaining further insights on the influence of magnetic properties and morphology on the cytotoxic potential.
References:
1. Magnetic Nanoparticles: Current Advances in Nanomedicine, Drug Delivery and MRI. Comanescu, C., Chemistry 2022, 4, 872-930.
2. Recent Advances in Surface Functionalization of Magnetic Nanoparticles, Comanescu, C. Coatings 2023, 13, 1772.
Acknowledgement:
This work is funded by the Core Program of the National Institute of Materials Physics, granted by the Romanian Ministry of Research, Innovation and Digitalization through the Project PC1- PN23080101 as well by the TE 91/2022, TE 86/2022 and TE 84/2002 projects
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