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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-22 1:37 |
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Conference: Bucharest University Faculty of Physics 2013 Meeting
Section: Solid State Physics and Materials Science
Title:
Spectral features of the Oligodynamic Effect of Silver
Authors:
Ana IOANID,Stefan ANTOHE
Affiliation:
Facultatea de Fizică, Universitatea din Bucuresti
E-mail
ana_ioanid@yahoo.com
Keywords:
oligodynamic effect, disulfide bond, ion-protein interaction, colloidal Ag(I) particles
Abstract:
Silver oligodynamic action consists to strong antimicrobial effect for extremely low metal concentrations. The entire mechanism of this action is still unknown, but his start is the binding of the metal ions to reactive groups of the target cell proteins resulting of the alteration both of theirs structure and function. We show an analysis of the UV-VIS absorbance spectra recorded successively up to 300 minutes, for the BSA-Ag(I) solution system. Spectra show any remarkable changes that can be associated with the evolution of the Ag(I) action. Our analysis proposes a mechanism of the Ag(I)-protein interaction involving homolytic cleavage of the S-S bond and stabilizes an elongated BSA molecule via fine colloidal Ag(I) particles.
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